Study description
PANDA project addresses the fragmented approaches in researching
emerging infectious diseases by adopting a comprehensive One Health
framework. This systemic approach helps identify key spillover
determinants and targets for effective, sustainable community-based
interventions.
Motivation
- Interactions at the human-animal environment interface drive zoonotic disease emergence.
- Human behaviors are recognized determinants of spillover.
- Lack in knowledge on how to effectively modify risk behaviors.
- Thailand and Laos are hotspots for
zoonotic disease emergence.
Aims
Synthesize the existing knowledge:
- Risk factors contributing to zoonotic spillover
- Human habitual behaviors
System analyses of study sites:
- Society and environment
- Literacy and behaviors
- Host animal populations and virome
Community-tailored 3PL intervention:
- Co-design pandemic prevention & preparedness literacy (3PL) intervention content
Social Sciences
Exploratory Sequential Mixed Methods
MAIN ACTIVITIES:
- In-depth interviews with key stakeholders
- Focus group discussions with the general population
- Participatory community mapping & observations with village health volunteers and animal health volunteers
- Quantitative surveys among general population to evaluate pandemic literacy
OBJECTIVES:
- Identify key stakeholders
- Determine structural drivers and barriers
- Environmental conditions of importance for spillover
FEATURES:
- Establish and assess human-animal and
human-environment interactions
- In-depth understanding of local knowledge
and perceptions
- Assess existing local capacities
- Identify information gaps
DETAILS:
- Establish and assess human-animal and
human-environment interactions
- In-depth understanding of local knowledge and perceptions
- Assess existing local capacities
Virology
Sample Collection & Virus Detection
MAIN ACTIVITIES:
- Biological samples collection from host animals
- Identification of viruses in animal hosts
- Viral spillover risk ranking
- Viruses with spillover potential
OBJECTIVES:
- Study the reservoir host animals
- Identify associated zoonotic viruses
- Classify spillover potential
FEATURES:
- Sampling of primary and secondary hosts and bushmeat
- Host risk ranking matrix
- Cutting-edge technology:
– pan-viral PCR for viral family screening
– viral hybridization-based capture technique
– viral metagenomics with high-througput sequencing
Intervention Science
Co-designed 3PL Intervention
MAIN ACTIVITIES:
- Develop the 3PL Intervention Based on existing One Health content and the output of previous activities
- Optimal design with local community engagement
- Village Health Volunteers and Animal Health Volunteers as channels
- Cluster Randomized Control Trial (cRCT) to evaluate the intervention
OBJECTIVES:
- Create the 3PL design
- Establish the 3PL impact
- Elucidate the 3PL modes of action
cRCT DESIGN:
- Clusters: Village Health Volunteers and households
- Two deliver arms: 3PL Intervention and Control
- Gender-balanced groups
cRCT OUTCOMES:
- Risk behaviors score
- Pandemic literacy
- Competencies and skills